Decreased Pregnane X Receptor Expression in Children with Active Crohns Disease
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چکیده
منابع مشابه
Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
Expression of the pregnane X receptor (PXR) has been reported to be decreased in animal models of inflammatory bowel disease (IBD). To investigate the differential expression of PXR in children with Crohn's disease, a type of IBD, RNA was extracted from archived intestinal biopsies from 18 children with Crohn's disease (CD) and 12 age- and sex-matched controls (aged 7-17yrs). The aim of this in...
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In this report we show that submicromolar concentrations of dexamethasone enhance pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human hepatocytes. Because this result is only observed after 24 h of cotreatment and is inhibited by pretreatment with cycloheximide, we further investigated which factor(s), induced by dexamethasone, might be responsible for this eff...
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P-glycoprotein (P-gp) limits bioavailability and accumulation of HIV protease inhibitors (PIs). PIs are ligands for the pregnane-X-receptor (PXR), which regulates P-gp expression. This occurs when ligands activate the receptor, initiating binding to response elements in the MDR1 promoter. PXR also activates cytochrome P4503A4 (CYP3A4) and a correlation between hepatic PXR and CYP3A4 mRNA has be...
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Received 8 August 2012 Revised 7 November 2012 Accepted 2 December 2012 Published Online First 5 January 2013 ABSTRACT Objective To assess the antifibrotic effects of pregnane X receptors (PXRs) in experimental dermal fibrosis. Methods The antifibrotic effects of PXR activation by 5-pregnen-3β-ol-20-one-16α-carbonitrile (PCN) were studied in the bleomycin model for prevention of dermal fibrosis...
متن کاملIn Silico Identification of Human Pregnane X Receptor Activators
The nuclear receptor member human pregnane X receptor (hPXR) regulates enzymes and transporters involved in xenobiotic detoxification as well as maintains homeostatic balance of bile acids, thyroid and steroid hormones. hPXR can be recognized and activated by a structurally diverse array of environmental chemicals and drug compounds to initiate adverse biological effects, such as perturbing nor...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2016
ISSN: 1521-009X
DOI: 10.1124/dmd.115.068742